Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease
Identifieur interne : 003809 ( Main/Exploration ); précédent : 003808; suivant : 003810Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease
Auteurs : Adrian P. Fawcett [Canada] ; Elena Moro [Canada] ; Anthony E. Lang [Canada] ; Andres M. Lozano [Canada] ; William D. Hutchison [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-03.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (physiopathology), Deep Brain Stimulation (instrumentation), Functional Laterality (physiology), Globus Pallidus (physiology), Globus Pallidus (surgery), Humans, Huntington Disease (diagnosis), Huntington Disease (physiopathology), Huntington Disease (surgery), Male, Neurosurgical Procedures (methods), Oculomotor Nerve (physiopathology), Saccades (physiology), Time Factors, basal ganglia, eye movements, oculomotor control.
- MESH :
- diagnosis : Huntington Disease.
- instrumentation : Deep Brain Stimulation.
- methods : Neurosurgical Procedures.
- physiology : Functional Laterality, Globus Pallidus, Saccades.
- physiopathology : Basal Ganglia, Huntington Disease, Oculomotor Nerve.
- surgery : Globus Pallidus, Huntington Disease.
- Adult, Humans, Male, Time Factors.
Abstract
Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in suppressing rapid saccades toward newly appearing stimuli. We measured several saccade parameters in an HD patient who had marked improvement of clinical symptoms with bilateral GPi DBS to determine whether oculomotor performance improved in parallel with clinical scores. Oculomotor performance was assessed using three testing paradigms: pro‐saccades, anti‐saccades, and memory‐guided saccades. The data from the HD patient was also compared to that of two healthy controls. Pallidal DBS decreased pro‐saccade latency, total movement time, and the number of correctly executed trials, as well as increasing saccade gain. Memory–saccade performance was negatively affected with stimulation: saccade gain decreased, latency increased, and the patient's ability to suppress unwanted saccades decreased with stimulation. Our data demonstrate a task‐specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20356
Affiliations:
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Lang</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Neurology, The Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, Division of Neurosurgery, The Toronto Western Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, Division of Neurosurgery, The Toronto Western Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-03">2005-03</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="371">371</biblScope><biblScope unit="page" to="377">377</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3921BD9DE80ECE74CBCDF9F3741C39CF5A617158</idno><idno type="DOI">10.1002/mds.20356</idno><idno type="ArticleID">MDS20356</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Basal Ganglia (physiopathology)</term><term>Deep Brain Stimulation (instrumentation)</term><term>Functional Laterality (physiology)</term><term>Globus Pallidus (physiology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (surgery)</term><term>Male</term><term>Neurosurgical Procedures (methods)</term><term>Oculomotor Nerve (physiopathology)</term><term>Saccades (physiology)</term><term>Time Factors</term><term>basal ganglia</term><term>eye movements</term><term>oculomotor control</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Globus Pallidus</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Huntington Disease</term><term>Oculomotor Nerve</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Time Factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in suppressing rapid saccades toward newly appearing stimuli. We measured several saccade parameters in an HD patient who had marked improvement of clinical symptoms with bilateral GPi DBS to determine whether oculomotor performance improved in parallel with clinical scores. Oculomotor performance was assessed using three testing paradigms: pro‐saccades, anti‐saccades, and memory‐guided saccades. The data from the HD patient was also compared to that of two healthy controls. Pallidal DBS decreased pro‐saccade latency, total movement time, and the number of correctly executed trials, as well as increasing saccade gain. Memory–saccade performance was negatively affected with stimulation: saccade gain decreased, latency increased, and the patient's ability to suppress unwanted saccades decreased with stimulation. Our data demonstrate a task‐specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Fawcett, Adrian P" sort="Fawcett, Adrian P" uniqKey="Fawcett A" first="Adrian P." last="Fawcett">Adrian P. Fawcett</name></region><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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